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The efficacy of working memory training in improving crystallized intelligence Nature Precedings
Tracy Alloway; Ross Alloway.
Crystallized intelligence (Gc) is thought to reflect skills acquired through knowledge and experience and is related to verbal ability, language development^1^ and academic success^2^. Gc, together with fluid intelligence (Gf), are constructs of general intelligence^3^. While Gc involves learning, knowledge and skills, Gf refers to our ability in tests of problem-solving, pattern matching, and reasoning. Although there is evidence that Gf can be improved through memory training in adults^4^, the efficacy of memory training in improving acquired skills, such as Gc and academic attainment, has yet to be established. Furthermore, evidence of transfer effects from gains made in the trained tasks is sparse^5^. Here we demonstrate improvements in Gc and academic...
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/3697/version/1
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The Genetic Signature of Perineuronal Oligodendrocytes Nature Precedings
Sara Szuchet; Joseph A. Nielsen; Gabor Lovas; Javier Martinez de Velasco; Dragan Maric; Lynn D. Hudson.
Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function of perineuronal oligodendrocytes is unknown; it was proposed that following injury, they may remyelinate denuded axons. We investigated these cells' potential. A combination of cell-specific tags, microarray technology and bioinformatics tools to identify gene expression differences between these subpopulations allowed us to capture the genetic signature of perineuronal oligodendrocytes. Here we report that perineuronal oligodendrocytes are configured for a dual role. As cells that embrace neuronal somata, they integrate a repertoire of transcripts designed to create their own code for communicating...
Tipo: Manuscript Palavras-chave: Developmental Biology; Genetics & Genomics; Neuroscience; Bioinformatics.
Ano: 2008 URL: http://precedings.nature.com/documents/1821/version/1
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The hypothesis of basic phenotype modules Nature Precedings
Thomas von Zelewsky.
The evolutionary events that allowed the rapid occurrence of metazoa are still enigmatic. The presumably oldest metazoan fossils are microscopic and occur just above 635 Ma, at the beginning of the Ediacaran period. Upon condition that the lack of macrofossils in the lower Ediacaran strata is real, the assumption of a sudden appearance of already complex, but still small animals that flourished during the first half of the Ediacaran is a reasonable option. Consequently, the emergence of the first macrofossils with metazoan affinity in mid Ediacaran strata would indicate a second leap in animal evolution. Here, these apparent leaps are explained in terms of a new concept of evolvability that is based on well definable developmental modules: A system based...
Tipo: Manuscript Palavras-chave: Developmental Biology; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4189/version/1
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The Neonatal Microbiome and Necrotizing Enterocolitis. Nature Precedings
Phillip I. Tarr; Barbara Warner; Erica Sodergren; William Shannon; Aaron Hamvas; Vincent Magrini; George Weinstock.
Necrotizing enterocolitis (NEC) is a devastating disorder that affects approximately 10% of premature infants. Its mortality remains high (15-30%), and its cause remains unknown. About 80% of cases occur within 35 days of birth among hospitalized newborns of low birth weight. Probiotics diminish the incidence and severity of NEC, and NEC does not occur antepartum. NEC affects a readily identifiable at-risk group, has a tightly defined interval before its onset, occurs in an organ system that is intimately associated with a microbial population in flux, has a plausible association with the intestinal microbiota, and cohorts at risk have rarely been studied in large numbers, or prospectively. This disorder, therefore, provides a unique opportunity to explore...
Tipo: Marker Paper / Data Plan Palavras-chave: Biotechnology; Developmental Biology; Genetics & Genomics; Microbiology; Bioinformatics; Data Standards.
Ano: 2010 URL: http://precedings.nature.com/documents/5285/version/1
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The origin of vertebrates and their symmetry, segmentation, chord and tubular nervous system Nature Precedings
Alexander Ermolenko; Elena A. Perepada.
Development of vertebrata begins with formation of a multicellular organism by ordered repeated division of a reproductive cell and nondisjunction of the new formed cells, which have kept connection by means of the extracellular matrix. Further there is a consecutive formation of organisms due to aggregation of similar structures: blastaea; segmentella, supersegmentella. Supersegmentella gave development to tunicates, hemichordates, chordates like lancelet and to predecessors of vertebrata. Segmentation of organisms is determined by aggregation of supergastraeas into one integrated. Symmetry is determined by structure-forming quality of extracellular matrix. Symmetry of primary organisms was radial; then radial-bilateral, and the first plane of symmetry...
Tipo: Manuscript Palavras-chave: Developmental Biology; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4164/version/1
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The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification Nature Precedings
Gizachew Tiruneh.
*Objective*: To investigate the best statistical models that describe the effect of physical activity on BMI.
*Design*: Cross-sectional analyses of physical activity and BMI data. 
*Subjects*: 107 obese, overweight, and healthy college students (mean duration of physical activity for the normal, overweight, and obese students: 89, 59, and 24 months, respectively; mean BMI for the normal, overweight, and obese students: 21.61, 27.07, and 35.54 kg/m2, respectively).
*Measurements*: Inverse linear, inverse logarithmic, and inverse logistics models were used to analyze survey data for physical activity (measured by both frequency and duration of exercise) and BMI. Gender, age, and physical intensity variables...
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/2758/version/5
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The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification Nature Precedings
Gizachew Tiruneh.
*Objective:* To investigate the best statistical models that describe the effect of physical activity on BMI.
*Design:* Cross-sectional analyses of physical activity and BMI data.Subjects: 107 obese, overweight, and healthy college students (mean duration of physical activity for the normal, overweight, and obese students: 89, 59, and 24 months, respectively; mean BMI for the normal, overweight, and obese students: 21.61, 27.07, and 35.54 kg/m^2^, respectively).
*Measurements:* Inverse linear, inverse logarithmic, and inverse logistics models were used to analyze survey data for physical activity (measured by both frequency and duration of exercise) and BMI. Gender, age, and physical intensity variables were also...
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/2758/version/2
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The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification Nature Precedings
Gizachew Tiruneh.
*Objective:* To investigate the best statistical models that describe the effect of physical activity on BMI.
*Design:* Cross-sectional analyses of physical activity and BMI data.Subjects: 107 obese, overweight, and healthy college students (mean duration of physical activity for the normal, overweight, and obese students: 89, 59, and 24 months, respectively; mean BMI for the normal, overweight, and obese students: 21.61, 27.07, and 35.54 kg/m^2^, respectively).
*Measurements:* Inverse linear, inverse logarithmic, and inverse logistics models were used to analyze survey data for physical activity (measured by both frequency and duration of exercise) and BMI. Gender, age, and physical intensity variables were also...
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/2758/version/3
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The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification Nature Precedings
Gizachew Tiruneh.
*Objective*: To investigate the best statistical models that describe the effect of physical activity on BMI.
*Design*: Cross-sectional analyses of physical activity and BMI data. 
*Subjects*: 107 obese, overweight, and healthy college students (mean duration of physical activity for the normal, overweight, and obese students: 89, 59, and 24 months, respectively; mean BMI for the normal, overweight, and obese students: 21.61, 27.07, and 35.54 kg/m2, respectively).
*Measurements*: Inverse linear, inverse logarithmic, and inverse logistics models were used to analyze survey data for physical activity (measured by both frequency and duration of exercise) and BMI. Gender, age, and physical intensity variables...
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/2758/version/4
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The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification Nature Precedings
Gizachew Tiruneh.
*Objective:* To investigate the best statistical models that describe the effect of physical activity on BMI.
*Design:* Cross-sectional analyses of physical activity and BMI data.Subjects: 107 obese, overweight, and healthy college students (mean duration of physical activity for the normal, overweight, and obese students: 89, 59, and 24 months, respectively; mean BMI for the normal, overweight, and obese students: 21.61, 27.07, and 35.54 kg/m^2^, respectively).
*Measurements:* Inverse linear, inverse logarithmic, and inverse logistics models were used to analyze survey data for physical activity (measured by both frequency and duration of exercise) and BMI. Gender, age, and physical intensity variables were also...
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/2758/version/1
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The Size-Weight Illusion Is Not an Illusion When Picking the Best Objects to Throw Nature Precedings
Qin Zhu; Geoffrey Bingham.
Heaviness perception involves a misperception of weight known, since the 19th century, as the Size-Weight Illusion ^1^. The larger of two objects of equal mass is reported to be lighter than the smaller when they are lifted. The illusion has been found to be reliable and robust. It persists even when people know that the masses are equal and handle objects properly ^2^. It has been exhibited by children of only 2 years of age ^3,4^. All this suggests that the effect might be intrinsic to humans. Although different hypotheses have been advanced to account for the illusion over the 100+ years it has been studied ^5-11^, its origin remains unknown. More recently, people's perception of optimal objects for long distance throwing was found to exhibit a...
Tipo: Manuscript Palavras-chave: Developmental Biology; Ecology; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4584/version/1
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The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts Nature Precedings
Aubie Shaw; Jerry Gipp; Wade Bushman.
The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer. We show here that paracrine Hh signaling exerts a non-cell autonomous effect on xenograft tumor growth and that Hh pathway activation in myofibroblasts alone is sufficient to stimulate tumor growth. Nine genes regulated by Hh in the mesenchyme of the developing prostate were found to be regulated in the stroma of Hh over-expressing xenograft tumors. Correlation analysis of gene expression in matched specimens of benign and malignant human prostate tissue revealed a partial 5 gene fingerprint of Hh-regulated expression in...
Tipo: Manuscript Palavras-chave: Cancer; Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/3682/version/1
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Tracing blastomere fate choices of early embryos in single cell culture Nature Precedings
Yunhan Hong; Haobin Zhao; Ni Hong; Zhendong Li; Meisheng Yi; Rong Liu; Mingyou Li; Yan Yan; Yongming Yuan; Chang Ming Li; Ruowen Ge; Jianxin Song.
Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages. Tracing blastomere fate choices at the single cell level in vitro has not been possible because of the inability to isolate and cultivate early blastomeres as single cells. Here we report the establishment of single cell culture system in the fish medaka, enabling the isolation and cultivation of individual blastomeres from 16- to 64-cell embryos for fate tracing at the single cell level in vitro. Interestingly, these blastomeres immediately upon isolation exhibit motility, lose synchronous divisions and even stop dividing in ≥50% cases, suggesting that the widely accepted...
Tipo: Manuscript Palavras-chave: Biotechnology; Developmental Biology; Molecular Cell Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4907/version/1
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Tracking patterns of body mass index and triceps skinfold thickness from childhood to young adulthood: a 12-year prospective cohort study in Slovenia Nature Precedings
Gregor Starc; Janko Strel.
OBJECTIVE: To examine tracking patterns of body mass index (BMI), triceps skinfold thickness (TSF), height and weight from childhood to young adulthood in a rapidly developing society.DESIGN: Prospective 12-year cohort study of the Slovenian children, born during 1990-1991.SUBJECTS: A subsample of 4 833 Slovenian children from the 1990-1991 national cohort (n = 21 777) who were included in the SLOFIT monitoring system from 1997 to 2008, with complete data at age 7 and 18 y.MEASUREMENTS: Height, weight and TSF were measured at ages 7, 11, 14 and 18 y. The IOTF BMI cutoff points were used to identify overweight and obesity. RESULTS: Height, weight, and BMI at age 18 y were well predicted from childhood and grew more predictable with age, while TSF was not....
Tipo: Manuscript Palavras-chave: Developmental Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/2902/version/1
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Transcriptional memory emerges from cooperative histone modifications Nature Precedings
Hans Binder; Lydia Steiner; Thimo Rohlf; Sonja Prohaska; Joerg Galle.
Background
Transcriptional regulation in cells makes use of diverse mechanisms to ensure that functional states can be maintained and adapted to variable environments; among them are chromatin-related mechanisms. While mathematical models of transcription factor networks controlling development are well established, models of transcriptional regulation by chromatin states are rather rare despite they appear to be a powerful regulatory mechanism.
Results
We here introduce a mathematical model of transcriptional regulation governed by histone modifications. This model describes binding of protein complexes to chromatin which are capable of reading and writing histone marks. Molecular interactions between...
Tipo: Manuscript Palavras-chave: Developmental Biology; Genetics & Genomics; Molecular Cell Biology; Bioinformatics.
Ano: 2011 URL: http://precedings.nature.com/documents/6507/version/1
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Transduction Pathways Regulating The Trophic effects of Saccharomyces boulardii in Rat small intestinal mucosa Nature Precedings
Jean-Paul Buts; Nadine De Keyser.
_S . boulardii_ is a probiotic yeast widely prescribed in a lyophilized form that determines in human and rat small intestine several effects including endoluminal secretion of enzymes and of polyamines, stimulation of microvillous enzymes, of sIgA ,increased production of the receptor for polymeric immunoglobulins by crypt cells, and enhanced D-glucose uptake.
Aim: The objective of this study was to determine the pathway(s) by which these effects generated by the yeast are transduced into the cell.
Methods: Litters of 6 growing Wistar rats each (30 days post partum) were treated with _S .boulardii_ (50[micro]g per g body wt) or with saline during 72 hours. For each animal, the cytosol was prepared from the whole mucosa...
Tipo: Manuscript Palavras-chave: Developmental Biology; Microbiology.
Ano: 2009 URL: http://precedings.nature.com/documents/3061/version/1
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Transformation of metabolism with age and lifestyle in Antarctic seals: a case study of systems biology approach to cross-species microarray experiment Nature Precedings
Andrey Ptitsyn; Shane Kanatous.
*_Background:_* The metabolic transformation that changes Weddell seal pups born on land into aquatic animals is not only interesting for the study of general biology, but it also provides a model for the acquired and congenital muscle disorders which are associated with oxygen metabolism in skeletal muscle. However, the analysis of gene expression in seals is hampered by the lack of specific microarrays and the very limited annotation of known Weddell seal (_Leptonychotes weddellii_) genes.

*_Results:_* Muscle samples from newborn, juvenile, and adult Weddell seals were collected during an Antarctic expedition. Extracted RNA was hybridized on Affymetrix Human Expression chips. Preliminary studies showed a detectable...
Tipo: Manuscript Palavras-chave: Developmental Biology; Ecology; Bioinformatics.
Ano: 2009 URL: http://precedings.nature.com/documents/3380/version/1
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Translational Oncogenomics and Human Cancer Interactome Networks Nature Precedings
I. C. Baianu.
An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology. Novel translational oncogenomics research is rapidly expanding through the application of advanced technology, research findings and computational tools/models to both pharmaceutical and clinical problems. A self-contained presentation is adopted that covers both fundamental concepts and the most recent biomedical, as well as clinical, applications. Sample analyses in recent clinical studies have shown that gene expression data can be employed to distinguish between tumor types as well as to predict outcomes. Potentially important applications...
Tipo: Manuscript Palavras-chave: Biotechnology; Cancer; Chemistry; Developmental Biology; Genetics & Genomics; Immunology; Molecular Cell Biology; Pharmacology; Bioinformatics.
Ano: 2011 URL: http://precedings.nature.com/documents/6190/version/2
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Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution Nature Precedings
Michael E. Baker.
Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced genome of _Trichoplax_, the simplest known animal, and in the genomes of three lophotrochozoans: _Capitella_, an annelid worm, _Helobdella robusta_, a leech, and _Lottia gigantea_, a snail. BLAST searches found an ERR in _Trichoplax_, but no ER. BLAST searches also found ERRs in all three lophotrochozoans and invertebrate-like ERs in _Capitella_ and _Lottia_, but not in _Helobdella_. Unexpectedly we find that the _Capitella_ ER sequence is...
Tipo: Manuscript Palavras-chave: Developmental Biology; Ecology; Evolutionary Biology.
Ano: 2008 URL: http://precedings.nature.com/documents/2170/version/1
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Trichoplax, the simplest known animal, contains an estrogen-related receptor: Implications for the evolution of vertebrate and invertebrate estrogen receptors Nature Precedings
Michael E. Baker.
Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. We searched recently sequenced genome of _Trichoplax_, the simplest known animal, and genomes from three lophotrochozoans: _Capitella_, a worm, _Helobdella robusta_, a leech, and _Lottia gigantea_, a snail, to elucidate the origins and evolution of ERs and ERRs. BLAST found an ERR in _Trichoplax_, but no ER. BLAST searches of the lophotrochozaons found ERRs in all three and invertebrate ERs in _Capitella_ and _Lottia_, but not in _Helobdella_. These database searches and a phylogenetic analyses indicate that invertebrate ERs...
Tipo: Manuscript Palavras-chave: Developmental Biology; Ecology; Evolutionary Biology.
Ano: 2008 URL: http://precedings.nature.com/documents/1863/version/1
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